Factors @ Stark Lab

Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	Data available
Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	S2	Kc167	BG3	OSC	HeLa
Sin3A (FBgn0022764)	cofactor	(-1.65/-4.19/-0.97)	3	◼	◼	◼	◼	◼

Factor activity

Celltype:
S2
Kc167
BG3
OSC
HeLa

Additional information

Sin3A [FlyBase] | Sin3A [FlyMine] | Sin3A [BDGP]

H. sapiens orthologues¹

SIN3B (HGNC:19354, ENSG00000127511), SIN3A (HGNC:19353, ENSG00000169375)

Functionally similar transcription factors and cofactors

Similarity:

Euclidean distance

TF	Euclidean distance (rank)
Kr-h1	2.110 (1)
sna	2.209 (2)
CG17181	2.211 (3)
wor	2.211 (4)
tll	2.238 (5)

All TFs

Cofactor	Euclidean distance (rank)
MTA1-like	1.561 (1)
tlk	1.718 (2)
bon	1.774 (3)
simj	1.997 (4)
l(3)mbt	2.175 (5)

All cofactors

Pearson correlation

TF	Pearson correlation (rank)
run	0.969 (1)
CG6654	0.956 (2)
CG8301	0.953 (3)
CG8388	0.950 (4)
scro	0.947 (5)

All TFs.

Cofactor	Pearson correlation (rank)
Mi-2	0.991 (1)
Pcl	0.986 (2)
MTA1-like	0.982 (3)
XNP	0.980 (4)
Caf1	0.980 (5)

All cofactors.

CDS DNA Sequence²

ATGATGAAACGCACTCGCGTAGACGAGGTGCAATTTGGCACACGACCCGTTCCTCAGACCTCCGGAGGTGTGGGCGTTGGTGTCGTCGGCGTAACTGGAGGTGGGCCAACATCCGGCGGCGGTGGCACTGCTACTGTGGGCGTCAATACGACGGGCGTTACCATTGGTACCGTCGTGCCCAGTGCTCATAACGCCACCATCAGCGGGATCGGTTCCATTCACCATCGCATCCTTACTCCACAGCATGGAGGAGCACAAACCATTGCCTATTTGCCGTCCACCACGCCGACGGCTACGAATTTGAAGACCACAACCTCGATTGTGGATAGCACTACCGCTGGAGGACCAGTAGGAGCAGGAGCACAGGTGGCCGTAGGAGTTGGCTCTGCAGCCGGCGGAGGAGGCGTGGTGGTCTCCACAGGGAGCACGGGAACGCAAACATTACAGTATACAACATCTTATAGTGTGGCTTCGATACAGGCTGGTGGAACTCTGAAAGCCAACACAGCGGATGGCGCGAACACGGTACAGATTCATGTCACAGGAGGAGGAGCTGCAAACAATCCTGCCAGTGCACAGACTGTTTCCAGCAGCTCACAAACGGGCACAATCCGTCAGCGTACAATCAGCGGCACCCAGACAGTGGCCACTGCAGTGGGTAATCTAGCCACGATTTCCCAGCAACAACCGGTTCAACAATCACCTTTGGGCAAGGCCCAAACGCCTCCATCGTCCGTGGTTGCCAACAGTATCCCAGTGGGTGGAACCACCCCACCACAAGGACAGTCGGGAAATGCCACGCCACGCTTAAAAGTGGAGGATGCGTTGAGCTACCTGGACCAAGTAAAGTACCAGTATGCAGACCAGCCGCAAATCTACAACAACTTCCTCGACATAATGAAGGAATTCAAGTCGCACTGCATCGACACACCCGGAGTGATTGAGCGAGTCTCCACACTCTTCAAGGGGCACACAGAGCTGATATACGGCTTCAACATGTTCTTACCGCCGGGTTACAAGATCGAAATTCATTCGGATGCTCTTGGCTGTTCGGTGCCGGTGGTTTCGATGCCCTCACCACCGGGAGCGCCAACGAGCACAGGAACGGTGCATATGCTCACCGGAAATAGTTCGATGTCCGGTGCCGGACATATCGCCATCAAGACGACCAATGCTGCGACTTTAACACCGGCAGCAGGGGCTGGAGCAGCGGCCGCAGCAGCAGCTGTGGCTCAGATTCAATCCGCTGGAGCTGTAAATCTAATGACCCACGGCGGAGCCTCGCTTACCCAGACCACTATTCATGCATTGCAACAGGCGACGCCTCCTCAATCACAATCTCCAGGCGGAGGTCATGTCCACGTGAGTGTAACAAACTCTACGGCAGCAAACGCCGTAGTGCCCGGACAGCCAGGCATCTCCGTATCGGCGCACAATGTACCGCAGAACTACTCGAGAGATCGAGAAAGGGCCACCATAACACCTACTGGGCAAGTGGCTGGAGCAGCGGCAAACGTGAATGCGTCTGCTAGTATAGTTGTCGGTGGACCTCCAACGCCCAATTCTCTAAGTGAGCTTAGCCCTCATGGAGGAGCAGGAGGTGGGCCAGGTGCGGGAGCGGCGCAGCACAATCTGCATCACATCCAGCAGGCGCATCAATCGATTTTGCTTGGGGAGACGGGACAGCAGAATCAGCCGGTGGAGTTCAATCACGCCATAACCTATGTAAATAAGATCAAGAATCGTTTCCAAAACCAGCCGGCCAAGTACAAGAAATTCCTCGAAATTCTGCACGATTATCAGAGGGAGCAAAAGGTGATGAAGGAGGGCAGCCTGAACCAGGGTAAAATGCTCACCGAGCAGGAGGTATACACGCAGGTGGCTAAGCTTTTTGGCCAGGATGAGGATTTGCTTAGAGAGTTTGGCCAGTTTCTTCCTGATGCCACCAACCACCAGTCCGGGCAGTACATGTCCAAGTCAGCGTCTGTGCACAATGACCATGGCAAGCGTCCCACGGCTACTTTAAGCGGTGGAGCTCACATAACCATGTCATCTGCTTCGCCAGCGCCAAGTGGATCCCCTCTGCATTTGGGTGCAACGACTCTTCCGCAGATCGACAAAAGCGCCCATGCAGCGGCCATAGGAAACCTTTCGGCGGTGAACACTAGTGTCAGCATTAAGACGTACAATAATAATCAGCAACAGCAGAATCATGTGATCGGTTCAGGGCTGAATGCGACGCGGAACGATATTCTCTTTGAGAAGGACTATCACGCGGGTCTGCAGCAGCAAGCGCATCAGCGAGGAGCTGGAGTTGGAGGCCATCATCATTTGGCCGGGACTGCAGCGGGCGCCAATATCGGACGGCCTGGAGTGGGAGCCAGCGTGATGGTGTCGTACGATAAAGAGCATCGAAATAATCATCATGTACAAAAGTACGTTGGCCACGCGCCAAACCAGAATCTAACGCATGGTCATAACGCAAAGAAATCACCAAGTTATGGCATTCCTTCGGTGATTGGTTCCATGCCGCACATTTCGGACAATTCGCTCGACCGCAGTTCACCGGGAATTAGTTACGCCACGCCACCATTGCCCTCTGGTCCACATGGACAGCATAACTCTGGTTCAGCTACGAGGAGGCCGGGTGATGACAGTTTAGTCGGACACTATGCTAGTGGAGCGCCGCCTGCTAAGCGACCGAAGCCTTATTGTCGTGATGTCAGCTTTTCCGAAGCATCGAGCAAGTGCACCATCTCCGACGCCGCGTTCTTTGACAAGGTGCGAAAGGCGTTGAGAAGTCCAGAGGTCTACGACAACTTCCTGCGATGCCTGACCCTTTTTAACCAGGAAATTGTCTCCAAAACGGAACTTCTTGGTCTGGTATCACCGTTCTTGATGAAGTTCCCCGACCTGCTGAGATGGTTCACCGACTTTCTGGGACCGCCCTCTGGTCAACCTGCTGGAGGATTGATTGACGGCATGCCCTTAGCCGCAACGCAACGTCAGGGAGGTGGAAGCAGTAATAGTTCCCATGATCGAGGTACCAGTCACCAGAGTGCCGCCGAGTATGTCCAGGATGTGGATCTGTCTTCTTGCAAGCGGCTGGGTGCATCCTATTGTGCTTTGCCGCAGTCCACAGTACCTAAGAAGTGCAGCGGACGGACGGCTCTCTGCCGGGAAGTGCTCAACGACAAATGGGTATCGTTCCCGACGTGGGCCAGCGAGGACTCCACTTTTGTTACATCGCGAAAAACTCAGTTCGAGGAGACAATTTACAGAACGGAGGACGAGCGATTCGAGCTGGACCTGGTCATCGAGGTTAATAGTGCCACGATTCGAGTGCTGGAGAACTTACAGAAGAAAATGTCACGAATGTCCACCGAGGAATTGAGCAAATTCCATCTGGACGATCATCTGGGCGGCACATCTCAAACGATACACCAGCGGGCCATTCATCGCATCTACGGCGACAAGTCGGGAGAGATAATCACGGGAATGAAGAAAAATCCGTTTGTGGCGGTGCCTATTGTACTGAAGCGACTGAAAGTCAAGGAGGAGGAGTGGCGAGAAGCGCAAAAGACCTTCAATAAGCAATGGCGGGAACAGAACGAGAAGTACTACCTCAAGTCTCTCGATCACCAGGCCATCAACTTTAAGCCCAACGACATGAAAGCCCTGCGCTCAAAGAGTCTGTTTAACGAAATCGAGACGCTGTACGATGAGCGGCACGACCAAGAGGACGACGCCATGGAACCGTTTGGGCCGCATCTGGTGCTGCCGTACAAGGATAAAACCATTCTGGACGATGCCGCCAACCTGCTGATTCATCATGTGAAGCGTCAGACTGGCATCCAGAAGCAGGAGAAGCAAAAGATTAAGCAGATCATCCGACAATTTGTGCCTGACCTTTTCTTCGCGCCGCGACAGCCACTAAGCGATGACGAACGCGATGACGATGACAATACGAAAATGGACGTGGACTCGCCACTGGGTCGCACGGAGTCTTCGACTCGAAATGCCAAGAGTACGCCCAGTGAAAGTGCCTCTCCGGCGCGTAGCAATGCAAGCACTAGCAGCGTAACACCAGCGGGAATTAAGAAAGAGACTGATGACTCGAAAGCGACGACAGGATCTTTTGCACCAGCGTCCTCGGCAACGGCATCTTCAGCGACGCCTGTGGACGATGCTACGCCATCAACATCCTCAGCAGCGGCGGCAGCATCAGCGGCATCGTCATCAACTGTTTCAGGAACCGAAGGCAAGCCAAAGGATGACCCCCTATCGTCGCACAAGGAAGAAGGAGCCGGTAGCACCAGCTCTGGAGTTGCCACGAGTCCCAGGCAAGCCCAAGACACTGCAGGAGCAGGCGTCGATGTGGAAATCAAACTGGAACATCCTGCGGACTTTTCCAATCCAAAGCTTCTACCGCCGCACGCGCACGGGCAACGCGAAGACGAATCCTACACGCTGTTCTTCGCTAACAACAATTGGTATTTATTCCTGCGGCTACATGCGATTCTCTGCGACCGTCTGCATGTTATGTATGAAAGAGCGCGTTTGCTGGCCATCGAGGAGGAGCGCTGTAGGGTGAATCGAAGGGAGAGCACAGCCACGGCGCTGCGGCTAAAGCCCAAACCGGAGATTCAAGTTGAAGACTACTACCCCACCTTCCTTGATATGCTCAAGAACGTCCTAGACGGCAACATGGACTCGAATACGTTCGAGGACACGATGCGTGAAATGTTTGGCATTTATGCCTACATCTCTTTCACGCTGGATAAGGTTGTCTCCAATGCTGTTCGCCAGCTGCAATATTGTGTCACAGAACGAGCCGCACTGGATTGTGTAGAGCTGTTTGCAACGGAGCAAAGGCGTGGCTGCACCGGAGGATTCTGTCGAGATGCGCACAAGACATTTGACAGGGAGATGTCGTATCAGCGGAAAGCTGAGAGCATTCTCAACGAGGAGAATTGCTTCAAAGTGTACATTTACAAAATCGATTGCCGTGTAACCATAGAGCTGCTTGATTCGGAGCCCGAGGAAGTCGATAAGCCGGCTGCGTTGAAGGCCCAGAAGTTCAGCAAGTATGTAGAGCGGTTGGCGAATCCTGCGCTCGGCGGTGGTGGCAATACTGGCCGCTCCGATTCGGCGCTCGGCAATGACAGCGTTGTAGATGGGTCCGATATCAAGACGGAGGCGGACGAAGATACTGCCGAGTTGCGCTACAGAGAAGGTGGAATCGGAGGAGCAGGCAAGGCGCGCTTTTTGGTGCGCAACAAGCGGAGATCAAAGCTGCTTGAGGAGCAAGTGCGTCAGTTGTTTGAACATAGGCGGAATCGGATTGAGCAGCATGGTACTGCGGCCTCACTTGAACCCATCTCCGTTGACAGTGCCATTTCAAGCAACAGCACCACCGGCGGTGGCGGCAGCGGCACTAATAACAACAATAATAATAATAATAATAACAACAGCTGGGGCGGCAAACGTCTGGAGAGGCTGGGCGCCCCACAGGTGGGCTTGGCCGAGCAATACGCCTTTAATGATCGCGACGAGATCAGCACAAATATCAGCAACGGGCGATGTTTTGTGACCAGCAAGAATCTCAAGCTACTTAAGTACGATGCAGTGCGTCGTGCCAAGAAGAGTCATTGCCGCGTAACTCAGGCGAAATACGCTCACTTCCAAACGTACGTTAACAAGTGGCTTCAGCAACATGTCAGCGAGCAACAGCAGCAGAACTGCGTCGACTGGCTGCTGGGCAAGACGGCAGACCAAATCAATGCCAGCGGCTGGGGATCCGCCAGCAAAACCAAGACGGTACAGCAGAAGGATACTTCGAAGACACCGTATCGCATCTACAACAGATACAGAGTGGTGCAGAGTGCAGTAAGCGGCGGTTTGATGAGTGCCACTGCTCCAACTCCAGATGGTTCAGTTCCGGCGGTCAATTCCGCGCCATCAGGCTCAGTTTCAACGGTGAACAATGTACAGGGCTCGGCGGCAGTATCCTCAACTTCCCACTCGATGTGCAACAGTAGCATTTTGTCCGCGGACTCCACCACCAATACCAATGCGTCAGCACAGCAGCAGCAGCATTGCAACAGTGCAGCAGCTGCAACAACACCGAATGCAGAGGCACTGCAACAGGTGCGACCCATGGAGAGC

CDS AA Sequence²

MMKRTRVDEVQFGTRPVPQTSGGVGVGVVGVTGGGPTSGGGGTATVGVNTTGVTIGTVVPSAHNATISGIGSIHHRILTPQHGGAQTIAYLPSTTPTATNLKTTTSIVDSTTAGGPVGAGAQVAVGVGSAAGGGGVVVSTGSTGTQTLQYTTSYSVASIQAGGTLKANTADGANTVQIHVTGGGAANNPASAQTVSSSSQTGTIRQRTISGTQTVATAVGNLATISQQQPVQQSPLGKAQTPPSSVVANSIPVGGTTPPQGQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAANVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDLLREFGQFLPDATNHQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHYASGAPPAKRPKPYCRDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAMEPFGPHLVLPYKDKTILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDDDNTKMDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNPKLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERARLLAIEEERCRVNRRESTATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRKAESILNEENCFKVYIYKIDCRVTIELLDSEPEEVDKPAALKAQKFSKYVERLANPALGGGGNTGRSDSALGNDSVVDGSDIKTEADEDTAELRYREGGIGGAGKARFLVRNKRRSKLLEEQVRQLFEHRRNRIEQHGTAASLEPISVDSAISSNSTTGGGGSGTNNNNNNNNNNNSWGGKRLERLGAPQVGLAEQYAFNDRDEISTNISNGRCFVTSKNLKLLKYDAVRRAKKSHCRVTQAKYAHFQTYVNKWLQQHVSEQQQQNCVDWLLGKTADQINASGWGSASKTKTVQQKDTSKTPYRIYNRYRVVQSAVSGGLMSATAPTPDGSVPAVNSAPSGSVSTVNNVQGSAAVSSTSHSMCNSSILSADSTTNTNASAQQQQHCNSAAAATTPNAEALQQVRPMES

¹ H. sapiens orthologs were obtained from InParanoid8, in particular D.melanogaster-H.sapiens.orthoXML.
² Genomic sequences of the transcription factors were obtained from the dm3/BDGP Release 5 genome assembly. In the case of cofactors, the genomic sequences stand for our results obtained by deep sequencing.