Factors @ Stark Lab

Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	Data available
Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	S2	Kc167	BG3	OSC	HeLa
H2.0 (FBgn0001170)	TF	(-1.20/-4.21/-0.19)	7	◼	◼	◼	◼	◻

Factor activity

Celltype:
S2
Kc167
BG3
OSC

Additional information

H2.0 [FlyBase] | H2.0 [FlyMine] | H2.0 [BDGP]

H. sapiens orthologues¹

HLX (HGNC:4978, ENSG00000136630)

Functionally similar transcription factors and cofactors

Similarity:

Euclidean distance

TF	Euclidean distance (rank)
Blimp-1	0.801 (1)
CG16778	0.884 (2)
retn	0.920 (3)
dve	0.948 (4)
Kr	1.011 (5)

All TFs

Cofactor	Euclidean distance (rank)
MBD-like	1.179 (1)
CtBP	1.463 (2)
H	2.487 (3)
bon	2.559 (4)
MTA1-like	2.743 (5)

All cofactors

Pearson correlation

TF	Pearson correlation (rank)
dve	0.983 (1)
Kr-h1	0.982 (2)
retn	0.981 (3)
NK7.1	0.980 (4)
bap	0.980 (5)

All TFs.

Cofactor	Pearson correlation (rank)
MBD-like	0.978 (1)
H	0.976 (2)
CtBP	0.964 (3)
Su(z)2	0.952 (4)
Psc	0.950 (5)

All cofactors.

CDS DNA Sequence²

ATGTTACTACACGAGAGTGCCGCCAGCATGGAACAGAGTATGCCCGAGAACCTCAGCACTCACATGTACGGCGAGTGTGAAGTGAATCCAACGCTGGCAAAGTGTCCCGATCCAGTGAATGTCGATCATGAGCTGCCCACCAAAGAATCCTGTGCCTCGACTACCATAGTCAGTACGTCGCCAACCAGCGCCACGAGCACCACCAAAGTCAAGCTGAGCTTCAGTGTGGATCGTCTGTTGGGCTCGGAACCCGAGGAATCCCACCGGCAGAGCTCCTCCTCGCCCTCGACCAAGTCATGCTGCGATGGCAGCATTCTAGCCTGCTGCTCCTTCCCCCACTGCTTCAGCCAGGCGAATGCCGAATCCCGTAGGTTTGGACATGCCACGCTTCCGCCCACTTTCACACCCACTTCATCGCACACGTACCCCTTCGTGGGTCTGGATAAGCTGTTCCCTGGCCCCTATATGGATTACAAATCAGTGCTCAGACCGACGCCAATTCGGGCAGCAGAACACGCCGCACCCACTTATCCCACGCTGGCTACCAATGCGCTCCTCCGCTTCCATCAACATCAGAAGCAGCAGCACCAGCAGCATCATCATCATCAGCACCATCCCAAACACCTCCATCAGCAGCACAAGCCCCCGCCACACAACTCGACGACAGCCTCGGCGCTACTGGCGCCGCTCCACAGCCTCACGAGCCTCCAGCTGACGCAACAGCAGCAGCGATTTCTGGGCAAGACGCCGCAGCAGCTCCTGGACATAGCGCCCACCTCGCCCGCCGCCGCCGCCGCTGCCACATCCCAGAACGGTGCACATGGACATGGAGGTGGCAATGGCCAGGGCAACGCCTCAGCCGGAAGCAATGGGAAGCGCAAGCGATCCTGGTCTCGCGCCGTCTTCTCGAATCTGCAGCGCAAGGGCCTGGAGATTCAGTTCCAGCAGCAGAAGTACATCACCAAGCCAGATCGCCGCAAGCTGGCGGCACGACTGAATCTCACCGACGCTCAGGTCAAGGTGTGGTTCCAGAACCGTCGCATGAAGTGGCGGCACACGCGCGAGAATCTGAAGAGTGGCCAGGAGAAGCAGCCGAGTGCAGTACCCGAATCCGGAGGTGTCTTCAAGACATCCACGCCATCCGGTGATGGTACGCCCCAGGAGGCACTCGACTACAGTTCCGATAGCTGCTCCAGTGTGGATTTGAGCGAGCAGGCCGACGAAGATGATAATATTGAAATCAATGTGGTGGAG

CDS AA Sequence²

MLLHESAASMEQSMPENLSTHMYGECEVNPTLAKCPDPVNVDHELPTKESCASTTIVSTSPTSATSTTKVKLSFSVDRLLGSEPEESHRQSSSSPSTKSCCDGSILACCSFPHCFSQANAESRRFGHATLPPTFTPTSSHTYPFVGLDKLFPGPYMDYKSVLRPTPIRAAEHAAPTYPTLATNALLRFHQHQKQQHQQHHHHQHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTPQQLLDIAPTSPAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWRHTRENLKSGQEKQPSAVPESGGVFKTSTPSGDGTPQEALDYSSDSCSSVDLSEQADEDDNIEINVVE

¹ H. sapiens orthologs were obtained from InParanoid8, in particular D.melanogaster-H.sapiens.orthoXML.
² Genomic sequences of the transcription factors were obtained from the dm3/BDGP Release 5 genome assembly. In the case of cofactors, the genomic sequences stand for our results obtained by deep sequencing.