Factors @ Stark Lab

Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	Data available
Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	S2	Kc167	BG3	OSC	HeLa
CG11085 (FBgn0030408)	TF	(-0.86/-3.78/0.07)	11	◼	◼	◼	◼	◼

Factor activity

Celltype:
S2
Kc167
BG3
OSC
HeLa

Additional information

CG11085 [FlyBase] | CG11085 [FlyMine] | CG11085 [BDGP]

H. sapiens orthologues¹

NKX1-2 (HGNC:31652, ENSG00000229544)

Functionally similar transcription factors and cofactors

Similarity:

Euclidean distance

TF	Euclidean distance (rank)
slp1	0.712 (1)
CG4360	0.833 (2)
Sry-beta	0.925 (3)
CG2199	0.941 (4)
abd-A	0.956 (5)

All TFs

Cofactor	Euclidean distance (rank)
CG14220	2.262 (1)
MBD-like	2.442 (2)
XNP	2.532 (3)
CtBP	2.560 (4)
Mi-2	2.792 (5)

All cofactors

Pearson correlation

TF	Pearson correlation (rank)
hkb	0.986 (1)
slp1	0.986 (2)
Sry-beta	0.985 (3)
abd-A	0.983 (4)
Sox21b	0.979 (5)

All TFs.

Cofactor	Pearson correlation (rank)
MBD-like	0.964 (1)
CtBP	0.951 (2)
H	0.951 (3)
Psc	0.917 (4)
Su(z)2	0.917 (5)

All cofactors.

CDS DNA Sequence²

ATGCAGAGCTCAAAATCTTTTTTAATACGCGATCTTCTGGGCGATTTGATTAATCGACGACAAACAGATTCGGAACTGGAGCTCTCCAACGACGATTCGGATATAGACATTGAGGATCGATCTACGCCGGACTCGACGGCTGCGGGCTGCCAGCAGGAGCTACTGCTGTCGCACCATCACCGCAGATTCACCCACCACGACGAATCCAGTGTGGAGTCCTGCCTATCGGCCACAAGGGGCCCCGGCTCTGGCACAGGATCGGGTGGTGGCGGAGGTGGTGGTGGTGGAGGAGGAGTAGCCAGCGGACTGAGCGCCGCTGCAGCGGCGGCGGGCGTGGCTGCTGGACTCCTGGCAGCGGCGGCCAGTGGTGCCAATGGGGATCGGGATGCCAACGGTGGCAGTGGCCCGGGATCCGGTGGCGGTACAAGTGGCGGCTATGCGGAGCACAAGCTGCAGCTGAGCAAAAGTGGCCGGAAGCCGCGACGCCGCCGAACCGCCTTCACCCACGCCCAGCTCGCCTACTTGGAGCGGAAGTTCCGGTGCCAGAAGTACCTGAGCGTGGCCGATCGCAGCGATGTGGCCGAAACGCTCAATCTGTCCGAGACGCAGGTGAAAACCTGGTACCAGAATCGCCGGACCAAATGGAAGCGACAGAATCAACTGCGTCTGGAGCAGCTGCGTCATCAGGCGACCATGGAGAAGGATTTTGTGGTCCAGGATGGCGGCGGTGCGGGCGGACTCGGCTGCTGTCCCAGCGGACTGAGCAGTTCTTTTAGTGCCGCCGCCGCTGCTGCAGCGGCTGCCAGCAATCCTTGCAATTTTCTCACTTCCGCCGCAGCGGCGGCCATTTTCCGTAATGTCGGCTATGTCCACGGATGTCCCATG

CDS AA Sequence²

MQSSKSFLIRDLLGDLINRRQTDSELELSNDDSDIDIEDRSTPDSTAAGCQQELLLSHHHRRFTHHDESSVESCLSATRGPGSGTGSGGGGGGGGGGGVASGLSAAAAAAGVAAGLLAAAASGANGDRDANGGSGPGSGGGTSGGYAEHKLQLSKSGRKPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVAETLNLSETQVKTWYQNRRTKWKRQNQLRLEQLRHQATMEKDFVVQDGGGAGGLGCCPSGLSSSFSAAAAAAAAASNPCNFLTSAAAAAIFRNVGYVHGCPM

¹ H. sapiens orthologs were obtained from InParanoid8, in particular D.melanogaster-H.sapiens.orthoXML.
² Genomic sequences of the transcription factors were obtained from the dm3/BDGP Release 5 genome assembly. In the case of cofactors, the genomic sequences stand for our results obtained by deep sequencing.