Factors @ Stark Lab

Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	Data available
Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	S2	Kc167	BG3	OSC	HeLa
Tfb4 (FBgn0031309)	cofactor	(-0.28/-2.93/0.25)	6	◼	◻	◻	◻	◻

Factor activity

Celltype:
S2

Additional information

Tfb4 [FlyBase] | Tfb4 [FlyMine] | Tfb4 [BDGP]

H. sapiens orthologues¹

GTF2H3 (HGNC:4657, ENSG00000111358)

Functionally similar transcription factors and cofactors

Similarity:

Euclidean distance

TF	Euclidean distance (rank)
Crg-1	1.765 (1)
RunxB	1.783 (2)
CG17361	1.840 (3)
exd	1.844 (4)
CG11317	1.867 (5)

All TFs

Cofactor	Euclidean distance (rank)
TfIIA-S-2	0.740 (1)
escl	0.812 (2)
CG18136	0.899 (3)
p16-ARC	0.954 (4)
UbcD6	1.047 (5)

All cofactors

Pearson correlation

TF	Pearson correlation (rank)
mor	0.953 (1)
Crg-1	0.942 (2)
CG11906	0.915 (3)
RunxB	0.914 (4)
Vsx2	0.901 (5)

All TFs.

Cofactor	Pearson correlation (rank)
Sce	0.986 (1)
escl	0.982 (2)
TfIIA-S-2	0.982 (3)
pr-set7	0.980 (4)
DNApol-delta	0.979 (5)

All cofactors.

CDS DNA Sequence²

ATGGAAGCAGATCAAGCAGCAAGCAAGGAAGCCGAATCATGCATCGACCTCTTGGTGATCGTCCTGGACACGAACCCCTCCCAGCACTTCGTGCGCCAGAACCCACAGAACCTCACGCAAATCCTGGAGGCGGTGATTGCCTTTGGGAATGCTCACCTGATGCAGAAGGCCCAGAACAAACTGGCTGTGGTATCCTGCTCCCACCATGCCACAAACTTCCTGTATCCGCTGCCCAGAAGACAAGTGGAACTGCGCCAAGTGGATGGGCAGTACGAGGCGTTTAATCTGGTGGAGAAGACGGTGAAGCAGCAGCTGGGCAGCATCCTGATGAACGCACCACGGCTCAGCGCTCCTTGTGAGAGTCTCCTGGCCGGCAGCATGTCCATGGCGCTGTGCTACATATCAAGGCTCCAGAGGAATCTGGCTCCTGGCGTCAAGATGCATTCCCGCATCCTGGTCGTCACAGGCAGCAACGAGTGCGCCTCGCAGTACATGACGTTCATGAACGTCTTCTTCACCGCCCAGAAACTGGGCATCACGATCGATACCTGCGCCCTGGACAAGACCCTCAGTTTGCTACAGCAAGGCTGTGACATTACCTCCGGACAGTTCCTCAAGGTCACCCAGCTGGACGGCCTGCTGCAGTACCTCCTGTGGGTCTTCCTGCCCGCCCCGCAGATCCGTCACAAATTGGTCCTGCCGCCACCGCCCAAAGTGGACTACCGCGCCTCCTGCTTCTGCCATCGTGAGCTGATCGACATTGGCTACGTCTGCTCGGTTTGCCTCTCGGTCTTCTGCAAATACAGTCCCATATGCACCACTTGCCACACCATTTTCAAGAATCCCGGTCCTCTGCCCATCAAGGGCAAAAAGAAAAAGAAGACCGACAAGCAAATG

CDS AA Sequence²

MEADQAASKEAESCIDLLVIVLDTNPSQHFVRQNPQNLTQILEAVIAFGNAHLMQKAQNKLAVVSCSHHATNFLYPLPRRQVELRQVDGQYEAFNLVEKTVKQQLGSILMNAPRLSAPCESLLAGSMSMALCYISRLQRNLAPGVKMHSRILVVTGSNECASQYMTFMNVFFTAQKLGITIDTCALDKTLSLLQQGCDITSGQFLKVTQLDGLLQYLLWVFLPAPQIRHKLVLPPPPKVDYRASCFCHRELIDIGYVCSVCLSVFCKYSPICTTCHTIFKNPGPLPIKGKKKKKTDKQM

¹ H. sapiens orthologs were obtained from InParanoid8, in particular D.melanogaster-H.sapiens.orthoXML.
² Genomic sequences of the transcription factors were obtained from the dm3/BDGP Release 5 genome assembly. In the case of cofactors, the genomic sequences stand for our results obtained by deep sequencing.