Factors @ Stark Lab

Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	Data available
Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	S2	Kc167	BG3	OSC	HeLa
Mi-2 (FBgn0262519)	cofactor	(-1.09/-3.59/-0.21)	7	◼	◻	◻	◻	◻

Factor activity

Celltype:
S2

Additional information

Mi-2 [FlyBase] | Mi-2 [FlyMine] | Mi-2 [BDGP]

H. sapiens orthologues¹

CHD4 (HGNC:1919, ENSG00000111642), CHD5 (HGNC:16816, ENSG00000116254), CHD3 (HGNC:1918, ENSG00000170004)

Functionally similar transcription factors and cofactors

Similarity:

Euclidean distance

TF	Euclidean distance (rank)
dpn	1.729 (1)
Doc2	1.756 (2)
HLHmgamma	1.816 (3)
fu2	1.872 (4)
CG2202	1.898 (5)

All TFs

Cofactor	Euclidean distance (rank)
Caf1-180	0.938 (1)
XNP	0.985 (2)
Su(var)3-3	1.081 (3)
Rpd3	1.345 (4)
Pcl	1.481 (5)

All cofactors

Pearson correlation

TF	Pearson correlation (rank)
run	0.964 (1)
CG6654	0.952 (2)
CG8388	0.950 (3)
CG8301	0.947 (4)
CG18011	0.946 (5)

All TFs.

Cofactor	Pearson correlation (rank)
Sin3A	0.991 (1)
Caf1-180	0.991 (2)
XNP	0.984 (3)
Pcl	0.983 (4)
Hrb87F	0.982 (5)

All cofactors.

CDS DNA Sequence²

ATGGCATCGGAGGAAGAGAATGACGATAATTTCCAGGAAGAAGAAGAGGCCCAGGAGGACAACGCACCTGCGGCGGAGCTGTCCAACGATTCCGACGCCCCTCTGAAGCCGAATAACGACGAAGACGACGACTACGATCCGGAGGACAGTCGCAGGAAGAAGAAGGGCAAGAAGCGCAAGACCAGGAAGGGCGAAGAGAAGGGTCGCAAGAAGAAGAAGCGCAAGAAGAACGAGAGCGAAGAGGACAGCGACTTTGTCCAGCACGATGAGGAGGTGGAGTACCCCAGCACCTCCAAGCGCGGTCGCAAGCGCAAGGAGGAGAAACAGGCCGCCAAGGAGAAGGAGTCGGCATCATCCGGAATGCCATCTGTGGAAGACGTGTGCTCAGCCTTTAGCGTCTGCAATGTGGAGATCGAGTACAGTGAGGAGGAGCTGCAGAGCCTAACGACCTACAAGGCTTTCATGCATCATGTTCGTCCGATTCTGCAGAAGGAAAACCCCAAGATTGCGGCACCAAAGCTAGTGATGCTGGTGGCAGCCAAGTGGCGTGAGTTCTGCGAGAGCAATCCGCACATCCAGCAGGAGGGTGGTGCCGCCGGCTCCGGTGGATCCGCCGGACAGGCACGCAGTGTGACAGGCGATGAGCCGGAGGAACCTCGATCATCGCGTTCCTCGCGCAACGAGAAACCGGATGACATTTACGAGGAGGCCGTCGAGGAGGAGGAAGAAGAGGAGGAGGAGGAGAAGAAACCTCGTCGTAAGCGCAGTGGACGTGGCAAGAAGGGGCGTCGTCCCTCCGGCAAGGTGCCCACTCTTAAGATTAAGCTGCTCGGCAAGCGCAAACGCGATAGTTCGGATGAGGAGCAAGATGCTAGCGGTGCATCGGAACGCGATTCGGATCTTGAGTTTGAACGGATGCTTCAGAAATCGGATGACAGTGCCGATGAAAAGGAGGCTCCTGTCTCCTCTAAGGCGGACAACTCAGCACCCGCTGCCCAGGACGATGGATCAGGAGCTCCAGTGGTGCGCAAGAAGGCCAAGACCAAGATCGGCAACAAGTTCAAGAAGAAGAATAAACTCAAGAAAACGAAGAACTTCCCGGAGGGCGAAGATGGCGAGCATGAGCACCAGGACTACTGCGAGGTGTGCCAGCAAGGAGGTGAGATCATCCTGTGCGACACCTGCCCTCGGGCATATCACTTGGTGTGCCTGGAGCCAGAACTGGATGAACCGCCAGAGGGCAAGTGGTCGTGTCCGCACTGCGAGGCTGACGGAGGTGCTGCTGAGGAAGAGGACGATGATGAGCACCAGGAATTCTGCCGCGTGTGCAAGGACGGTGGCGAGTTGCTGTGCTGCGACTCATGTCCCTCCGCCTATCACACATTCTGCTTGAATCCGCCTCTGGACACTATACCCGATGGCGATTGGCGCTGTCCTCGTTGCAGCTGCCCTCCGCTCACTGGCAAGGCTGAGAAGATCATCACCTGGCGATGGGCACAGCGTAGCAATGACGACGGTCCCTCCACCTCGAAGGGATCAAAGAACAGTAACTCCCGGGTGCGCGAGTACTTTATCAAGTGGCACAACATGTCCTACTGGCATTGCGAATGGGTGCCCGAAGTGCAACTGGACGTCCATCATCCGCTCATGATTCGTTCGTTCCAGCGCAAGTACGACATGGAAGAACCGCCCAAGTTCGAGGAGTCGCTGGATGAGGCGGACACTCGTTACAAGCGTATTCAGCGACACAAGGACAAGGTTGGCATGAAGGCAAACGATGATGCCGAAGTGCTGGAGGAGCGGTTCTACAAGAATGGCGTCAAGCCAGAGCGGCTCATTGTTCAGCGCGTAATCAACCATCGTACGGCAAGAGATGGCAGCACCATGTATCTGGTGAAGTGGCGCGAGTTGCCCTATGACAAGTCCACCTGGGAAGAAGAGGGTGATGACATACAGGGCCTGCGACAAGCCATCGATTACTATCAGGATCTGCGTGCGGTTTGCACCTCGGAGACAACTCAGTCGCGCAGCAAAAAGAGCAAGAAGGGTCGCAAGTCCAAGCTCAAGGTCGAGGACGACGAGGATCGCCCGGTCAAGCACTACACACCGCCGCCGGAAAAGCCAACTACTGATCTGAAGAAGAAGTATGAGGATCAGCCGGCTTTCTTGGAGGGCACTGGCATGCAATTGCATCCCTACCAGATCGAGGGCATTAACTGGTTGCGCTACAGCTGGGGCCAGGGCATCGACACCATCCTGGCCGACGAGATGGGTCTGGGTAAGACCATTCAGACGGTCACCTTCCTGTACTCTTTGTACAAGGAGGGCCATTGCCGCGGACCCTTCCTCGTGGCCGTGCCACTCTCGACGCTAGTGAACTGGGAGCGTGAGTTTGAGCTGTGGGCTCCGGACTTTTACTGCATCACGTATATCGGTGACAAGGACTCGAGAGCGGTTATACGGGAGAACGAGCTGAGCTTCGAGGAGGGCGCCATTCGTGGTAGCAAGGTTTCGCGTTTGCGGACCACCCAGTATAAATTCAACGTACTGCTGACTAGCTACGAGCTGATCTCCATGGACGCTGCTTGCCTTGGCAGCATTGACTGGGCCGTGCTCGTGGTGGACGAGGCCCATCGCTTGAAGAGCAACCAGAGCAAGTTCTTCCGTATCCTGAACAGCTACACTATTGCCTACAAGCTTCTGCTCACCGGCACACCGCTGCAGAACAATCTCGAGGAGCTGTTCCATCTGCTCAACTTCTTGAGCCGCGACAAGTTCAATGATCTGCAGGCCTTCCAGGGCGAATTCGCTGACGTTTCGAAGGAGGAGCAGGTTAAGCGTCTGCACGAGATGCTTGGACCGCACATGCTGCGTCGTTTGAAGACGGATGTGCTGAAGAACATGCCGTCCAAGTCTGAGTTTATCGTGCGCGTCGAGCTGTCGGCCATGCAGAAAAAGTTCTACAAGTTCATCTTGACCAAGAACTACGAGGCTTTGAATTCAAAGAGCGGTGGTGGCTCTTGCTCACTGATCAACATTATGATGGACCTAAAGAAGTGCTGCAACCATCCGTATCTCTTCCCCTCGGCCGCCGAGGAGGCAACCACCGCTGCCGGTGGTCTCTACGAGATTAACTCGCTGACCAAGGCTGCTGGCAAGCTGGTCCTGCTATCCAAGATGCTGAAGCAGCTGAAGGCACAAAACCATCGTGTCTTGATTTTCTCCCAGATGACCAAGATGTTGGACATTCTCGAGGACTTCCTCGAGGGCGAGCAGTACAAGTACGAACGTATTGACGGTGGAATCACAGGAACATTGCGTCAGGAAGCCATTGATAGGTTCAATGCACCCGGAGCGCAGCAGTTTGTCTTCTTGCTGAGTACTCGAGCCGGAGGATTGGGTATTAATTTGGCCACGGCCGACACTGTCATTATTTATGACTCCGATTGGAATCCCCACAACGATATTCAGGCCTTCTCCCGAGCCCATCGTATTGGCCAGGCTAACAAGGTGATGATCTATCGATTTGTTACTCGAAATTCTGTGGAGGAGCGCGTTACCCAGGTGGCCAAGCGTAAGATGATGTTGACTCATCTTGTGGTCCGTCCGGGAATGGGCGGTAAAGGCGCTAACTTTACAAAGCAAGAACTGGACGATATCCTTCGTTTCGGTACCGAGGATCTGTTCAAGGAGGATGACAAGGAGGAAGCTATCCACTATGACGACAAGGCGGTGGCCGAGCTGCTCGACAGAACCAACCGCGGTATCGAGGAGAAGGAGTCCTGGGCCAACGAGTATCTGTCCTCGTTTAAGGTGGCTTCGTACGCCACTAAAGAAGAGGAGGAGGAGGAAGAGACGGAGATTATTAAACAGGATGCCGAGAACTCTGATCCGGCGTACTGGGTGAAGCTGCTGCGGCATCACTATGAACAGCACCAGGAAGATGTGGGTCGCAGCCTGGGCAAGGGCAAGCGCGTCCGCAAACAGGTCAACTACACGGATGGCGGCGTTGTGGCGGCTGATACCACGCGGGATGATTCCAACTGGCAGGACAACGGCAGCGAGTATAACTCCGAGTATTCAGCTGGCTCCGATGAGGATGGCGGTGACGATGACTTCGATGACCAGAATGGCGCAGAGAGAAAGGCCAAGCGGCGATTGGAGCGTCGCGACGATCGTCCATTGCCTCCACTGTTGGCCCGCGTGGGTGGAAACATCGAGGTGCTCGGTTTTAATGCCCGTCAACGCAAGAGCTTCCTCAATGCCATTATGCGGTACGGAATGCCGCCGCAAGATGCCTTCAACTCGCAATGGCTAGTCCGGGATTTGCGTGGTAAATCGGAGCGCAATTTTAAGGCGTATGTTTCTCTGTTTATGCGGCATCTTTGCGAGCCGGGAGCGGACAATGCGGAAACCTTTGCCGATGGTGTGCCGCGCGAAGGACTATCCCGCCAGCATGTGCTCACCCGGATCGGAGTGATGTCGCTAATTCGAAAGAAGGTACAGGAATTCGAGCATATTAACGGATACTACAGCATGCCGGAGCTCATTCTCAAGCCGTGCGAGCCCGTACGATCAGCCCTGAAACAGGATGTGGCGGCACTTGAAGCTCCGCCTACCGGTGGCAATGTCGACAAGAGCGCTACTACTAGCAATAGCGTCACTCCAGCCACCAGTGCGGCTCCCAGTCCAGCGCCAGCCTCTGAAAAAGGTGAAGACAAAGACAAGGACTCCGAAAAGGAGAAGGATAAGACCTCGGCGGAGAAGAGCGAGGTGAAGCAAGAACAAGAGGCTGAAGAGGACAAGAAGCCTGGGGATGTCAAGCAGGAGAACCCTGTGGAAGAAGCTGCCGGCGACACAAAGCCCAGCGACGCGGAGGTCAAAACCGAGGTGGCTAAAACAGAACCCAAGGAAGAGACCAAGGACCCGGAGGTAAAGGAGGAGCCCAAGACCGAAGAGAAGGAAAAAGAAAAGGTGGATGACAAGAAACCAATACCACCGACGACAGTAATTGACGACGACGATGACGATGTGATGATTGTCAAGGAGGACGGTGAGCTAGAAAAGCCCAGTGCCAGTTCACCCAAGGATCAAAAGGCAGTCGCCGCTGCTACGTCTGCTGCAACTGGAGCCACTGGCAAGGGAGCGGAGGACAGCTTGGAGGTGCTAAAGCGCAAATTTATGTTCAACATCGCCGACGGCGGGTTCACCGAACTGCACACTTTGTGGCTCAACGAGGAGAAGGCTGCCGTTCCTGGGCGAGAATACGAGATCTGGCACCGTCGCCACGACTACTGGCTGTTGGCCGGAATTGTGACCCATGGCTATGGCCGTTGGCAGGATATACAAAACGATATCCGTTTCGCGATCATAAACGAACCTTTCAAGATGGACGTTGGTAAGGGCAACTTTCTGGAAATCAAAAACAAGTTCCTGGCCCGGCGTTTTAAGTTGCTGGAGCAGGCGCTGGTCATCGAGGAGCAGCTGCGGCGAGCGGCCTACCTTAACCTCGCCCAGGACCCCAGTCACCCGGCAATGTCGCTAAACGCCCGTTTCGCAGAGGTCGAATGCCTGGCTGAATCCCATCAGCATCTGAGCAAGGAATCGCTGGCCGGTAACAAGCCCGCAAACGCTGTTCTGCACAAGGTGCTCAACCAGCTCGAAGAGCTGCTCTCGGACATGAAGAGCGATGTGTCCCGGCTGCCAGCTACACTGGCTCGCATCCCACCTGTTGCGCAACGGCTTCAGATGTCCAAGAGATCGATTCTCTCCCGACTGGCGGCCACCGCCGGAAATGCCTCCAATGCAGCTCAATTGATGGCACAATTCCCGGCTGGATTCCAGGGCACAACATTGCCAGCATTCACGAGCGGACCGGCTGGCAACTTTGCCAACTTTCGGCCACAGTTCTCGGTGCCCGGCCAGCTATCGAATAATTCCGGCGTC

CDS AA Sequence²

MASEEENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNNDEDDDYDPEDSRRKKKGKKRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPERLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAAVPGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIPPVAQRLQMSKRSILSRLAATAGNASNAAQLMAQFPAGFQGTTLPAFTSGPAGNFANFRPQFSVPGQLSNNSGV

¹ H. sapiens orthologs were obtained from InParanoid8, in particular D.melanogaster-H.sapiens.orthoXML.
² Genomic sequences of the transcription factors were obtained from the dm3/BDGP Release 5 genome assembly. In the case of cofactors, the genomic sequences stand for our results obtained by deep sequencing.