Factors @ Stark Lab

Gene Name Type Activity (log2) in S2 cells
(avg/min/max)
Cluster Data available
S2Kc167BG3OSCHeLa
Iswi (FBgn0011604) cofactor
 
(-1.17/-4.04/-0.24)

Factor activity

Additional information

Iswi [FlyBase] | Iswi [FlyMine] | Iswi [BDGP]

H. sapiens orthologues1

SMARCA5 (HGNC:11101, ENSG00000153147), SMARCA1 (HGNC:11097, ENSG00000102038)

Functionally similar transcription factors and cofactors

CDS DNA Sequence2

ATGTCCAAAACAGATACAGCTGCCGTGGAGGCAACCGAAGAGAACTCGAACGAGACGACTTCAGATGCGGCCACCAGTTCATCCGGTGAAAAGGAGGCTGAGTTCGACAACAAAATCGAGGCTGATCGCAGTAGGCGCTTTGATTTCCTGCTAAAGCAGACGGAGATATTCACCCACTTCATGACTAACAGCGCTAAGAGTCCCACGAAGCCTAAGGGTAGACCCAAGAAGATCAAAGACAAGGACAAGGAAAAGGATGTGGCCGATCATCGTCATCGCAAGACAGAGCAGGAGGAGGATGAGGAGTTGCTGGCGGAAGACTCGGCCACCAAGGAGATCTTTCGCTTCGATGCCTCACCCGCCTACATCAAAAGTGGAGAGATGCGTGACTACCAGATTCGCGGTCTTAACTGGATGATTTCGCTTTACGAAAATGGTATCAATGGAATTCTGGCCGATGAAATGGGTCTAGGAAAGACCCTGCAGACCATATCTCTGCTGGGTTACCTCAAGCATTTCAAAAATCAAGCTGGACCACACATCGTCATCGTGCCAAAGTCAACGCTTCAGAATTGGGTAAATGAGTTTAAAAAGTGGTGTCCTTCCCTCAGAGCCGTCTGCCTTATTGGTGACCAGGACACCCGTAACACCTTCATTAGAGATGTGCTCATGCCTGGCGAGTGGGACGTTTGCGTGACCTCCTATGAGATGTGTATCCGCGAGAAGTCTGTATTCAAGAAGTTCAACTGGCGCTATTTGGTCATCGACGAGGCGCATCGTATCAAGAACGAGAAGTCGAAGCTGTCGGAGATTCTGCGAGAGTTTAAGACCGCTAATCGTCTACTTATCACGGGTACTCCGCTGCAGAATAACCTCCACGAGCCGTGGGCCCTGCTTAATTTCCTGCTGCCCGATGTGTTTAATTCGTCAGAGGATTTTGACGAATGGTTCAACACGAACACCTGCCTGGGTGACGATGCATTGATTACGCGTTTGCATGCCGTGCTGAAACCTTTCCTGCTCCGTCGTCTAAAGGCCGAAGTGGAGAAGCGTCTGAAGCCGAAGAAGGAGATGAAAATATTTGTGGGTCTATCCAAGATGCAACGCGACTGGTACACCAAGGTGCTGCTTAAGGACATTGATGTAGTGAACGGTGCTGGCAAAGTGGAGAAGATGCGACTGCAGAACATCCTTATGCAGCTCCGCAAGTGCACCAACCACCCATATTTGTTTGATGGCGCCGAGCCCGGTCCGCCATACACCACGGACACGCATTTGGTGTATAACTCCGGAAAGATGGCTATTCTGGACAAGCTGCTGCCCAAGCTCCAAGAGCAGGGATCGCGTGTGTTGATTTTCTCACAAATGACGAGGATGTTGGATATCCTCGAGGACTACTGTCACTGGCGCAACTACAACTATTGCCGCCTGGATGGTCAGACGCCGCACGAAGATCGTAACAGGCAGATTCAGGAATTTAACATGGACAACAGCGCCAAGTTTCTCTTCATGTTGTCCACCCGAGCCGGTGGTTTGGGTATCAATTTGGCTACCGCTGATGTTGTCATCATTTACGACTCGGATTGGAATCCTCAAATGGATTTGCAAGCTATGGATCGTGCTCATCGTATTGGTCAAAAGAAGCAAGTGCGCGTTTTCCGGCTGATCACCGAAAGTACAGTGGAGGAGAAGATCGTGGAGAGAGCAGAGGTCAAGCTCCGTCTGGACAAGATGGTCATCCAGGGGGGCAGATTGGTTGACAACCGCTCCAATCAGTTGAACAAGGATGAAATGCTTAATATAATCCGTTTTGGAGCTAACCAAGTGTTCAGCTCTAAGGAGACAGACATTACCGATGAGGACATCGATGTTATTTTGGAGCGCGGTGAGGCCAAGACGGCCGAGCAAAAGGCAGCACTGGACAGTCTGGGCGAGAGTTCGCTGCGGACGTTCACAATGGACACAAACGGCGAGGCAGGAACTTCTTCCGTATATCAATTCGAGGGTGAGGATTGGCGCGAGAAGCAAAAGCTAAATGCGCTGGGCAACTGGATCGAGCCACCGAAGCGTGAACGCAAAGCCAACTATGCTGTGGATGCCTATTTCCGCGAGGCTCTCCGTGTCTCCGAACCCAAGGCACCGAAGGCTCCCCGCCCACCCAAGCAGCCTATCGTTCAGGACTTTCAGTTCTTCCCACCCCGTCTGTTTGAGCTGCTCGACCAGGAAATCTACTATTTCCGCAAGACTGTTGGTTACAAGGTGCCCAAGAACACGGAACTAGGATCGGATGCCACCAAAGTGCAGCGCGAGGAGCAGCGCAAGATCGATGAGGCAGAGCCGCTTACCGAGGAAGAGATCCAGGAGAAGGAGAATCTACTCTCACAGGGTTTCACTGCCTGGACCAAGCGCGATTTCAACCAGTTCATCAAGGCTAACGAAAAGTACGGTCGGGATGATATTGACAACATTGCCAAGGACGTGGAGGGCAAGACTCCGGAGGAGGTTATCGAGTACAACGCCGTGTTTTGGGAGCGATGCACTGAGTTGCAGGATATTGAGCGAATAATGGGACAGATTGAGCGTGGAGAGGGCAAGATTCAACGGCGATTGTCTATTAAGAAGGCTTTGGATCAAAAGATGTCGCGGTATCGCGCCCCCTTCCATCAGTTGCGGCTGCAATATGGTAATAACAAGGGCAAGAATTACACTGAAATAGAGGATCGCTTTCTGGTATGCATGCTTCACAAGTTGGGCTTTGACAAGGAGAATGTCTACGAAGAGCTGCGAGCGGCTATAAGAGCTTCTCCGCAATTCCGCTTTGACTGGTTCATCAAATCTAGAACCGCTTTGGAGCTACAGCGTCGCTGCAACACGTTGATTACCCTTATTGAACGTGAAAACATTGAGCTGGAAGAGAAAGAACGCGCCGAGAAAAAGAAAAGGGCACCAAAGGGCAGCGTGTCCGCTGGAAGTGGAAGTGCCAGCTCGAACACTCCAGCACCCGCGCCCCAACCGAAGGCCAGTCAAAAGCGGAAGAGCGAGGTGGTGACAACCAGTTCCAACTCGAAAAAGAAGAAGAAG

CDS AA Sequence2

MSKTDTAAVEATEENSNETTSDAATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSAKSPTKPKGRPKKIKDKDKEKDVADHRHRKTEQEEDEELLAEDSATKEIFRFDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHEPWALLNFLLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLITLIERENIELEEKERAEKKKRAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSEVVTTSSNSKKKKK

1   H. sapiens orthologs were obtained from InParanoid8, in particular D.melanogaster-H.sapiens.orthoXML.
2   Genomic sequences of the transcription factors were obtained from the dm3/BDGP Release 5 genome assembly. In the case of cofactors, the genomic sequences stand for our results obtained by deep sequencing.