Factors @ Stark Lab

Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	Data available
Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	S2	Kc167	BG3	OSC	HeLa
Chd3 (FBgn0023395)	cofactor	(-0.32/-3.19/0.18)	12	◼	◻	◻	◻	◻

Factor activity

Celltype:
S2

Additional information

Chd3 [FlyBase] | Chd3 [FlyMine] | Chd3 [BDGP]

H. sapiens orthologues¹

None.

Functionally similar transcription factors and cofactors

Similarity:

Euclidean distance

TF	Euclidean distance (rank)
exd	1.492 (1)
RunxB	1.711 (2)
unc-4	2.004 (3)
CG11317	2.010 (4)
CG17361	2.055 (5)

All TFs

Cofactor	Euclidean distance (rank)
TfIIA-S-2	0.996 (1)
vnc	1.049 (2)
Taf10	1.090 (3)
Tfb4	1.229 (4)
TfIIA-S	1.238 (5)

All cofactors

Pearson correlation

TF	Pearson correlation (rank)
mor	0.954 (1)
exd	0.935 (2)
RunxB	0.917 (3)
unc-4	0.891 (4)
Crg-1	0.889 (5)

All TFs.

Cofactor	Pearson correlation (rank)
S6kII	0.983 (1)
Etl1	0.981 (2)
vnc	0.979 (3)
CG8289	0.976 (4)
Orc1	0.975 (5)

All cofactors.

CDS DNA Sequence²

ATGTCGTCTAAGAGAGGGGCTGATCCAGACTGGAAAACACCTGGCAAGGCTTCCAAGGACAAGCGGCCGAAAACCAATGCCAAGAAGCAGAAGTTTCGCGACGAAGAATACTGCAAAGTTTGTAGTGATGGAGGAGATCTGCTGTGCTGCGATTCCTGCCCTTCCGTTTACCACAGAACCTGTCTGAGTCCTCCCTTGAAATCGATTCCCAAAGGCGATTGGATCTGCCCGCGCTGCATTCCCTTGCCCGGAAAAGCCGAGAAGATATTGTCATGGCGCTGGGCCCTCGATCGAAGCGTGGAGCTTCGTACATCTAAAGGTGAAAAGCGGCGCGAGTACTTTATCAAGTGGCATGGCATGTCCTACTGGCACTGCGAATGGATTCCCGAAGGTCAAATGCTCTTGCACCATGCCTCAATGGTTGCCAGCTTCCAGAGAAGGAGCGACATGGAAGAGCCAAGTCTCGAGGAGCTCGATGATCAGGACGGCAATCTGCACGAGCGATTCTACAGATACGGCATTAAGCCGGAGTGGCTCCTTGTCCAGCGGGTTATCAATCATAGTGAGGAGCCCAATGGAGGGACTATGTACTTGGTGAAATGGCGTGAGTTGTCTTATAACGATAGCAGCTGGGAAAGAGAAAGCGACAGTATCCCGGGTCTAAACCAGGCTATCGCTCTCTACAAGAAACTACGGTCCAGTAATAAGGGACGTCAAAGAGATAGACCTGCACCCACAATAGACCTGAATAAGAAGTACGAGGATCAGCCAGTATTCTTGAAGGAGGCTGGCCTTAAATTGCATCCCTTTCAGATAGAGGGCGTCAGTTGGCTTCGCTATAGTTGGGGCCAAGGCATCCCCACCATACTGGCTGACGAGATGGGTCTGGGCAAGACCATTCAGACCGTGGTTTTTCTTTACTCACTATTTAAGGAGGGACATTGCCGCGGACCCTTCCTCATATCCGTGCCGCTTTCCACACTGACCAATTGGGAGCGAGAGCTGGAGCTCTGGGCTCCAGAACTATACTGTGTCACCTATGTGGGCGGCAAGACTGCTAGAGCGGTTATCCGGAAACATGAGATAAGCTTCGAGGAGGTAACCACCAAAACCATGCGCGAAAACCAAACCCAGTATAAGTTTAACGTAATGCTGACCAGCTACGAGTTTATCTCTGTGGACGCAGCCTTTCTCGGGTGCATCGATTGGGCGGCGCTGGTCGTGGACGAGGCCCATCGGCTAAGGAGCAACCAGAGCAAGTTTTTTAGGATCCTGAGCAAGTACCGCATCGGCTACAAGCTGCTGCTGACCGGCACTCCGCTTCAGAACAATCTCGAGGAGCTGTTCCATCTGCTCAATTTCCTGAGCTCTGGAAAGTTTAACGACCTGCAGACCTTCCAGGCCGAGTTCACTGACGTTTCGAAGGAAGAGCAAGTGAAGCGACTGCACGAGATCTTGGAACCGCATATGCTCCGTCGCCTTAAGGCGGATGTATTGAAGAGCATGCCCCCAAAGTCGGAGTTCATTGTGCGCGTGGAGCTGTCGTCTATGCAAAAAAAATTCTACAAGCATATTTTGACCAAAAACTTCAAGGCCTTAAATCAGAAAGGCGGCGGTCGCGTGTGTTCGCTGCTCAACATCATGATGGACCTGAGAAAGTGCTGCAATCATCCGTACCTGTTCCCCTCCGCCGCCGAGGAGGCCACTATCTCGCCAAGTGGTCTTTACGAGATGAGTTCGCTGACCAAAGCTTCCGGCAAGCTAGATTTACTGTCAAAGATGCTAAAACAGCTAAAGGCGGACAATCACAGGGTCCTTTTATTCTCCCAGATGACCAAGATGCTGAATGTTCTCGAACACTTCCTCGAAGGGGAGGGATACCAGTACGATCGCATCGACGGGTCGATCAAAGGCGATTTACGTCAGAAGGCCATTGACAGATTCAATGATCCCGTATCGGAGCACTTTGTCTTCCTGCTGAGCACTCGTGCAGGCGGACTGGGTATCAATTTGGCAACAGCCGACACCGTCATTATTTTCGACTCGGACTGGAATCCGCACAACGACGTTCAGGCCTTTTCCCGAGCCCATCGCATGGGGCAGAAAAAGAAGGTAATGATCTACCGATTTGTGACCCACAACTCGGTGGAGGAGCGCATTATGCAGGTTGCCAAGCACAAGATGATGCTCACCCATCTTGTGGTGCGCCCGGGAATGGGTGGCATGACAACAAATTTCTCAAAGGACGAGCTCGAAGACATCCTTCGCTTTGGCACCGAGGATCTTTTTAAGGACGGCAAGAGTGAGGCTATTCACTACGACGACAAAGCGGTGGCCGATCTGCTTGACCGCACCAATCGCGGCATTGAAGAGAAGGAGTCTTGGGCCAACGAGTATCTTTCGTCCTTTAAGGTCGCTTCTTATGCCACTAAGGAAGATCACGAGGAGCATGATGACTACAATAACGATGCTGAAAACACTGACCCATTCTACTGGGAAAACCTGATGGGAAAAAGTCAGCCGAAGCTACCAAAGAAGCAAAAGAAGCAGTCGCAGCAGTCCCAGGTGGACGTCGAGAGCATCATGGGAAAGGGCAAGCGAATCCGAAAGGAAATCGACTACTCCAATCAATATCCCTCTCCAAATCGAGCCACCCCAAGCAGTATAGTATTAATG

CDS AA Sequence²

MSSKRGADPDWKTPGKASKDKRPKTNAKKQKFRDEEYCKVCSDGGDLLCCDSCPSVYHRTCLSPPLKSIPKGDWICPRCIPLPGKAEKILSWRWALDRSVELRTSKGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIEEKESWANEYLSSFKVASYATKEDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIMGKGKRIRKEIDYSNQYPSPNRATPSSIVLM

¹ H. sapiens orthologs were obtained from InParanoid8, in particular D.melanogaster-H.sapiens.orthoXML.
² Genomic sequences of the transcription factors were obtained from the dm3/BDGP Release 5 genome assembly. In the case of cofactors, the genomic sequences stand for our results obtained by deep sequencing.