Factors @ Stark Lab

Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	Data available
Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	S2	Kc167	BG3	OSC	HeLa
pnr (FBgn0003117)	TF	(-1.19/-3.86/-0.39)	7	◼	◼	◼	◼	◻

Factor activity

Celltype:
S2
Kc167
BG3
OSC

Additional information

pnr [FlyBase] | pnr [FlyMine] | pnr [BDGP]

H. sapiens orthologues¹

GATA4 (HGNC:4173, ENSG00000136574), GATA6 (HGNC:4174, ENSG00000141448), GATA5 (HGNC:15802, ENSG00000130700)

Functionally similar transcription factors and cofactors

Similarity:

Euclidean distance

TF	Euclidean distance (rank)
grn	0.646 (1)
bap	0.716 (2)
Dr	0.729 (3)
dve	0.917 (4)
Sox21b	0.950 (5)

All TFs

Cofactor	Euclidean distance (rank)
MBD-like	1.396 (1)
CtBP	1.774 (2)
XNP	2.428 (3)
bon	2.534 (4)
Mi-2	2.620 (5)

All cofactors

Pearson correlation

TF	Pearson correlation (rank)
Dr	0.986 (1)
grn	0.984 (2)
hbn	0.979 (3)
bap	0.977 (4)
Sry-beta	0.976 (5)

All TFs.

Cofactor	Pearson correlation (rank)
MBD-like	0.968 (1)
H	0.951 (2)
CtBP	0.941 (3)
CoRest	0.925 (4)
Su(z)2	0.925 (5)

All cofactors.

CDS DNA Sequence²

ATGGGCATCTTACTGAGTGATGGCGATTCCACATCGGATCAGCAGTCGACTCGCGACTATCCCCACTTCAGCGGCGACTATCAGAACGTGACGCTGTCGGCTGCCTCTGCATCCACATCCGCATCCGCTTCTGCCACCCACGTCGCCGCCGTCAAGATGTACCACAGTAGCGCCGTTGCGGCATACACGGACCTGGCTGCCGCCGGTAGTGCCGCAAGCGCCGGAGTCGGAGTCGGGGTGTCCGGCTATCACCAGCAGGCGGTAAACGCTCCCGTTTACGTGCCATCCAACCGACAGTACAACCACGTGGCCGCTCATTTTGGAAGCGCTGCGGCGCAGAATGCCTGGACCACGGAAGGATTCGGATCGGCGCATGCACAGTTCTACTCGCCAAACGCCGCTGTGATGATGGGCTCGTGGCGCAGTGCCTACGATCCGTCGGGCTTCCAAAGATCCTCGCCCTACGAGAGCGCTATGGACTTCCAGTTTGGCGAGGGACGCGAGTGCGTCAATTGCGGTGCCATATCGACTCCGTTGTGGCGACGGGATGGAACCGGACACTATCTGTGCAACGCCTGCGGACTGTACCATAAGATGAACGGAATGAACCGGCCGCTGATCAAGCCTAGCAAGCGCCTGGTGAGTGCAACTGCCACTCGGAGGATGGGCTTGTGCTGCACCAACTGCGGCACTCGGACCACCACACTTTGGAGGCGCAACAACGATGGCGAACCCGTGTGCAATGCCTGCGGACTGTACTACAAGTTGCACGGTGTTAACAGACCACTGGCCATGAGGAAGGATGGCATTCAGACCAGGAAACGAAAGCCCAAGAAAACGGGAAGTGGTTCGGCGGTGGGAGCGGGCACTGGATCCGGAACAGGCTCCACTTTGGAGGCCATCAAGGAGTGCAAGGAGGAGCATGATCTCAAACCCTCGCTCAGCCTGGAGCGCCATAGCCTCAGTAAGCTGCACACGGATATGAAGAGCGGCACCAGCAGTAGTAGCACCTTGATGGGACATCACAGCGCGCAGCAGCAGCAGCAGCAGCAACAGCAACAACAACAGCAACAGCAGCAGCAGCAGCAGCAATCGGCACACCAACAATGCTTTCCCCTTTACGGACAGACGACGACGCAACAGCAGCACCAGCAACATGGCCACAGCATGACATCATCCTCTGGACAGGCACATCTGAGTGCCCGCCACCTTCACGGAGCGGCAGGAACGCAGCTCTACACGCCCGGCAGCAGTTCCGGCGGAGGCAGTGCGTCTGCCTACACATCGCACAGTGCGGAGACGCCGGCCCTGAGCAACGGAACTCCCTCGCCCCATTACCAGCACCACCACCACCTCGGCGGAACCCATGGACACCATGTGACGGCAGCGGCGGCACATCATCATTTCCATGCCGCTGCCGCTGTGGCCGCCTACGGCGTAAAGACAGAGGCGAGTGCCACCAACTACGACTATGTGAACAACTGCTACTTTGGGGGCACCTTCGGTGCGCTGGGAGGAGCTGCAACCACAACCGCCATGGCTGGCGGAGCGGCCAGTGAACTGGCTGGCTACCATCACCAGCACAACGTCATCCAGGCAGCCAAACTGATGGCCACCTCG

CDS AA Sequence²

MGILLSDGDSTSDQQSTRDYPHFSGDYQNVTLSAASASTSASASATHVAAVKMYHSSAVAAYTDLAAAGSAASAGVGVGVSGYHQQAVNAPVYVPSNRQYNHVAAHFGSAAAQNAWTTEGFGSAHAQFYSPNAAVMMGSWRSAYDPSGFQRSSPYESAMDFQFGEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKRLVSATATRRMGLCCTNCGTRTTTLWRRNNDGEPVCNACGLYYKLHGVNRPLAMRKDGIQTRKRKPKKTGSGSAVGAGTGSGTGSTLEAIKECKEEHDLKPSLSLERHSLSKLHTDMKSGTSSSSTLMGHHSAQQQQQQQQQQQQQQQQQQQQSAHQQCFPLYGQTTTQQQHQQHGHSMTSSSGQAHLSARHLHGAAGTQLYTPGSSSGGGSASAYTSHSAETPALSNGTPSPHYQHHHHLGGTHGHHVTAAAAHHHFHAAAAVAAYGVKTEASATNYDYVNNCYFGGTFGALGGAATTTAMAGGAASELAGYHHQHNVIQAAKLMATS

¹ H. sapiens orthologs were obtained from InParanoid8, in particular D.melanogaster-H.sapiens.orthoXML.
² Genomic sequences of the transcription factors were obtained from the dm3/BDGP Release 5 genome assembly. In the case of cofactors, the genomic sequences stand for our results obtained by deep sequencing.