Factors @ Stark Lab

Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	Data available
Gene Name	Type	Activity (log2) in S2 cells (avg/min/max)	Cluster	S2	Kc167	BG3	OSC	HeLa
Orc1 (FBgn0022772)	cofactor	(-0.58/-3.44/0.30)	12	◼	◻	◻	◻	◻

Factor activity

Celltype:
S2

Additional information

Orc1 [FlyBase] | Orc1 [FlyMine] | Orc1 [BDGP]

H. sapiens orthologues¹

ORC1 (HGNC:8487, ENSG00000085840)

Functionally similar transcription factors and cofactors

Similarity:

Euclidean distance

TF	Euclidean distance (rank)
exd	1.818 (1)
unc-4	1.945 (2)
RunxB	2.017 (3)
D1	2.148 (4)
Lhr	2.154 (5)

All TFs

Cofactor	Euclidean distance (rank)
Sirt7	0.974 (1)
pr-set7	1.198 (2)
CG8289	1.268 (3)
Caf1-105	1.270 (4)
14-3-3zeta	1.279 (5)

All cofactors

Pearson correlation

TF	Pearson correlation (rank)
mor	0.935 (1)
exd	0.926 (2)
CG11317	0.908 (3)
unc-4	0.905 (4)
RunxB	0.904 (5)

All TFs.

Cofactor	Pearson correlation (rank)
Chd3	0.975 (1)
Sirt7	0.974 (2)
Caf1-105	0.973 (3)
CG9246	0.973 (4)
Iswi	0.969 (5)

All cofactors.

CDS DNA Sequence²

ATGGTTAATAAAGAGAACGCCCGCAGTGTGGGCCAGCAGGTGAAGTGGATCGGAAGCCAAGACGAACTGCCGCCGGTGAAGAATCTGGAGCACAAGAACGTCTACTTCTACCAGAAGTGCATCTACGGTCCGCTGACTTTGTCCGTTGGCGACTTTATACTGGTGTCGAACGCGGATGCCGCCGAGCCGGACACAGTGAGTGGATGCGACGTGGCCCGGATCCTGCACATGTACGAGCTGCGCGAGCTGACCGATCGCGAGCCCTGCCGCGCCATCGTCCAGTGGTACTCCTGGCCGAAAGCCATTCCGCACAACAAATACGACGACGACGAGGTGGCCATAGACTTTAGCCTGGAGGTGATCGAGGAGCATCGCCCGTACGACAACGACGTGGCCCTCGGTGCCATCTATCGCAAGTGCATCGTGCTGGAGGGTACCTCAAAAACGTCAGCGGAGGAGATTCTCAAACGACACGCCAACAAACTGAAGTCCACGGCCTGCCCCATGTTTGTCAGCCGGTACAGGTTTGTCAAGGTGAAGCGGAGCTATCGCTTGATTCCCTTGGAAATTCACTTGGAGCAGCCGGAGGACAATGCCAGGCCAACCCGCTCATCTCGCAAATCCCTAACTGCACACAGAGAATCCAAGCGATCAATATCCGCCCGCCACGATGACACAGCTGGCAACAAGGGATCCTCAGTGGAAAAACGACGACGTGCGTCCATGGCAGCCTCGAGTTCCGTGGAGTTCATCGATGTCAACAGCTTCATCTGCGAGAATAAAGTGTCGCCAATTAAGATCGTGGGCGGACGCAGTGTCGTCCGGTTGTCTGAGAAGAAAAATGCTCCGGAGATCAATGCCAACTATCTGCCGGCTTCGCCTCTCACTGAGAAGAACGCCAAGGTGGAGACACCGAAATCCCGGGCCTCGGCAGCCCGCCGCAACCTAAATCTCAGCCTGGATCGCGGAGCCGACACCACAGCCGACTCAGACTGCCTGAACTACTCCATTGTTCAGCAGACTCCCGATCCTAAAACGCCTTCCAACGACATGAAGATCAAGCTGCGCCTTTCGGAGAGAAGGCGTTCGGTGCGCCTCGCATCCATGGACGTGGATCCCTTGTCGTTAGAGGAGGCCGTACAAGAACCCAATGCCCAGGGACGCAAGCGATTGGGCGTGGCCAATGGCGATATCTACCATACGCCCACCAAGAAATCCAAAGAGCCTCTGGAATCAGCTGCAGCTACCGAGCAAACGCCCTCGACGAGGCGTAAAAGCATCCTGAAATCAGCAACTAGTCGATTGGCCGAGGGCACGCCCAGGCGCAGTATTCACCTCTCGAACATTGTGGAGCAGCGCGTGTTTGAGGATGATGAAATAATATCCACTCCGAAAAGGGGGCGCTCGAAGAAAACAGTTCAAGACAATGACGAGGACTATTCGCCAAAGAAATCGGTCCAAAAGACGCCAACACGAACGCGTCGGTCAAGCACCACCACCAAAACAGCGACGACACCCAGCAAAGGGATCACAACCGCAACTGCAACCCCGATGACGCCCTCCCAAAAGATGAAGAAGATACGAGCCGGTGAACTTAGTCCCAGCATGCAACAGCGCACTGACCTTCCGGCCAAGGATTCCAGCAAATCCGAACTGCAGCTAGCACGCGAACAGCTTCATGTGTCTGTTGTGCCAAAGAGTTTGCCGTGCCGAGAACGGGAATTCGAGAACATTTACGCCTTTCTGGAGGGCAAGATCCAGGATCAGTGCGGCGGCTGCATGTATGTGTCCGGAGTTCCGGGCACTGGCAAAACAGCCACTGTCACTGGCGTCATACGCACCCTGCAGAGGATGGCTAAACAGAATGAGCTGCCTGCCTTTGAGTATCTGGAGATTAATGGCATGCGACTGACTGAGCCGCGTCAGGCCTACGTCCAGATCTACAAACAGCTCACGGGCAAGACTGTGTCCTGGGAGCAGGCACACGCTCTGCTAGAGAAACGGTTCACTACTCCGGCGCCGCGTAGAGTTACCACTGTGCTGCTGGTTGATGAGCTGGATATCTTGTGCAACCGGCGCCAAGATGTGGTCTACAATTTGCTCGACTGGCCCACCAAGTCGGCGGCCAAGCTGGTAGTGGTCACCATTGCCAACACCATGGACTTGCCTGAGCGCTTGCTGATGGGTAAAGTCACCTCTCGTCTTGGACTTACCCGTCTCACATTCCAGCCGTACAGCCACAAGCAGCTGCAAGAGATCGTTACCGCCCGCCTGGGAGGATCGGAGACTTTTAAAGGCGAGGCCGTGCAGCTGGTGGCGCGCAAGGTAGCCGCCGTTTCCGGTGATGCTCGCCGAGCTCTGGACATCTGCCGGCGTGCTACAGAAATTGCTGATACGGCTGCGGTCAAGTGCGTCACAATGCTGCACGTGCAGCAGGCATTGGCCGAGATGATAGCCAGTGCCAAGGTGCAGGCCATTAGGAACTGTTCGCGGATGGAGCAGATCTTCTTGCAGGCAATTGCAGCTGAAGTTACGCGCACTGGCGTCGAGGAGACGACTTTCATGGGCGTCTATCAGCAGGTGGAAACTATTGCCGCCTTCATGGGCGTGACCTTTCCACCACCAGGACGCGCCCTGCGCTTGTGCTCCAAGCTGGGCGCCGAGCGACTCATCATCAGTGAACATTCCCGCAATGACCTCTTTAAGAAAATCCTGCTCAACGTCAGCGCTGATGACATTCACTACGCCCTCAGAGTGGAAGAGATGGTCAAC

CDS AA Sequence²

MVNKENARSVGQQVKWIGSQDELPPVKNLEHKNVYFYQKCIYGPLTLSVGDFILVSNADAAEPDTVSGCDVARILHMYELRELTDREPCRAIVQWYSWPKAIPHNKYDDDEVAIDFSLEVIEEHRPYDNDVALGAIYRKCIVLEGTSKTSAEEILKRHANKLKSTACPMFVSRYRFVKVKRSYRLIPLEIHLEQPEDNARPTRSSRKSLTAHRESKRSISARHDDTAGNKGSSVEKRRRASMAASSSVEFIDVNSFICENKVSPIKIVGGRSVVRLSEKKNAPEINANYLPASPLTEKNAKVETPKSRASAARRNLNLSLDRGADTTADSDCLNYSIVQQTPDPKTPSNDMKIKLRLSERRRSVRLASMDVDPLSLEEAVQEPNAQGRKRLGVANGDIYHTPTKKSKEPLESAAATEQTPSTRRKSILKSATSRLAEGTPRRSIHLSNIVEQRVFEDDEIISTPKRGRSKKTVQDNDEDYSPKKSVQKTPTRTRRSSTTTKTATTPSKGITTATATPMTPSQKMKKIRAGELSPSMQQRTDLPAKDSSKSELQLAREQLHVSVVPKSLPCREREFENIYAFLEGKIQDQCGGCMYVSGVPGTGKTATVTGVIRTLQRMAKQNELPAFEYLEINGMRLTEPRQAYVQIYKQLTGKTVSWEQAHALLEKRFTTPAPRRVTTVLLVDELDILCNRRQDVVYNLLDWPTKSAAKLVVVTIANTMDLPERLLMGKVTSRLGLTRLTFQPYSHKQLQEIVTARLGGSETFKGEAVQLVARKVAAVSGDARRALDICRRATEIADTAAVKCVTMLHVQQALAEMIASAKVQAIRNCSRMEQIFLQAIAAEVTRTGVEETTFMGVYQQVETIAAFMGVTFPPPGRALRLCSKLGAERLIISEHSRNDLFKKILLNVSADDIHYALRVEEMVN

¹ H. sapiens orthologs were obtained from InParanoid8, in particular D.melanogaster-H.sapiens.orthoXML.
² Genomic sequences of the transcription factors were obtained from the dm3/BDGP Release 5 genome assembly. In the case of cofactors, the genomic sequences stand for our results obtained by deep sequencing.